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Dysfunction of the vitamin D endocrine system as common cause for multiple malignant and other chronic diseases.

Optimal vitamin D status for colorectal cancer prevention: a quantitative Meta-analysis. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, et al. Evaluation of vitamin D repletion regimens to correct the vitamin D status in adults. Pepper KJ, Judd SE, Nanes MS, Tangpricha V. The vitamin D epidemic and its health consequences.

Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The shortened dosing interval over 10 consecutive days might result in higher compliance. Overall, the 10-day oral D3 regimen rapidly and effectively normalized 25(OH)D levels. The 600,000 IU D2 single mega-dose decreased 25(OH)D3 levels by an average of 4 ng/mL in 37 subjects. The difference between the 2 mean increments was highly significant: P=3.15.10-18. The mean increment in 25(OH)D for the D3 group was 47.03 (23.67) ng/mL over a mean of 36.9 (2.9) days. The mean total 25(OH)D increment from baseline was 10.33 (5.68) ng/mL over a mean of 43.08 (2.81) days for the D2 group. Baseline and follow-up total serum 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were compared. Fifty-one subjects received 600,000 IU D2 orally and 54 subjects received a total dose of 500,000 IU D3 administered orally, as 50,000 IU D3 daily for 10 consecutive days.

The aim of this study was to compare the effect of 2 high-dose oral vitamin D regimens-a 10-day course of D3 500,000 IU versus a single mega dose of 600,000 IU D2-on serum 25(OH)D levels.Ī prospective cohort study was conducted from September 2010 to February 2011 in an urban university tertiary hospital in Amman, Jordan.Ī total of 109 patients aged 18 to 79 years were enrolled with severe vitamin D deficiency. It has been reported that D2 supplements are less effective and may enhance the degradation of 25-hydroxyvitamin D3 (25D3) metabolite. Vitamin D is available in 2 forms: D2 (ergocalciferol) and D3 (cholecalciferol). Most regimens in current use are based on daily dosing, which may raise concerns of dosage inadequacy and suboptimal patient compliance. The correction of vitamin D deficiency is crucial for optimal skeletal and non-skeletal health.